Mimicry of Dopamine 1 Receptor Signaling with Cell-Penetrating Peptides
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چکیده
منابع مشابه
Cell Penetrating Peptides
During the last ten years it has been observed that a number of peptides and proteins are able to penetrate the cell membrane and enter the cell. Furthermore, it has been shown that even many cargo molecules that are covalently attached to these peptides will be translocated into the cell. Peptides that show the ability to translocate through the cell membrane are usually short peptides of less...
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The plasma membrane separates the interior and exterior of the cell by functioning as a barrier, which regulates and restricts entry of molecules into the cell. Consequently, the plasma membrane imposes a major hurdle for passage of many hydrophilic pharmaceutical agents into the cell. A group of peptides, denoted cell-penetrating peptides (CPPs) was found about a decade ago to be able to trans...
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Arginine-rich cell-penetrating peptides are short cationic peptides capable of traversing the plasma membranes of eukaryotic cells. While successful intracellular delivery of many biologically active macromolecules has been accomplished using these peptides, their mechanisms of cell entry are still under investigation. Recent dialogue has centered on a debate over the roles that direct transloc...
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Cell-penetrating peptides can translocate across the plasma membrane of living cells and thus are potentially useful agents in drug delivery applications. Disulfide-rich cyclic peptides also have promise in drug design because of their exceptional stability, but to date only one cyclic peptide has been reported to penetrate cells, the Momordica cochinchinensis trypsin inhibitor II (MCoTI-II). M...
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DLBCL (diffuse large B-cell lymphoma) is the most common subtype of non-Hodgkin's lymphoma. Current therapy for patients includes chemotherapy and monoclonal antibodies. Although oncogene-targeted therapy is dramatically successful for patients with certain kinds of leukaemias, there are no such agents yet for DLBCL. One reason for this is that several key oncogenes involved in DLBCL pathogenes...
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ژورنال
عنوان ژورنال: International Journal of Peptide Research and Therapeutics
سال: 2020
ISSN: 1573-3149,1573-3904
DOI: 10.1007/s10989-020-10066-y